Stadium: Crypto.com Arena
Home Manager: Craig Berube Away Manager: Todd McLellan
| NHL | 2021/03/18 02:00 | STL Blues v LA Kings | L | 1-4 |
| NHL | 2021/03/07 02:00 | STL Blues v LA Kings | L | 3-4 |
| NHL | 2021/03/06 02:00 | STL Blues v LA Kings | W | 3-2 |
| NHL | 2021/02/25 02:30 | LA Kings v STL Blues | L | 2-1 |
| NHL | 2021/02/23 01:00 | LA Kings v STL Blues | L | 3-0 |
| NHL | 2021/01/25 01:00 | LA Kings v STL Blues | L | 6-3 |
| NHL | 2021/01/24 01:00 | LA Kings v STL Blues | W | 2-4 |
| NHL | 2019/12/24 03:00 | STL Blues v LA Kings | W | 4-1 |
| NHL | 2021/04/17 22:00 | STL Blues v ARZ Coyotes | L | 2-3 |
| NHL | 2021/04/14 23:30 | COL Avalanche v STL Blues | L | 4-3 |
| NHL | 2021/04/11 00:00 | MIN Wild v STL Blues | W | 2-3 |
| NHL | 2021/04/10 00:00 | MIN Wild v STL Blues | W | 1-9 |
| NHL | 2021/04/08 01:00 | VGS Golden Knights v STL Blues | W | 1-3 |
| NHL | 2021/04/06 00:00 | VGS Golden Knights v STL Blues | L | 6-1 |
| NHL | 2021/04/04 01:00 | STL Blues v COL Avalanche | L | 1-2 |
| NHL | 2021/04/03 01:00 | STL Blues v COL Avalanche | L | 2-3 |
| NHL | 2021/04/15 02:00 | VGS Golden Knights v LA Kings | L | 6-2 |
| NHL | 2021/04/13 02:00 | VGS Golden Knights v LA Kings | L | 4-2 |
| NHL | 2021/04/11 02:30 | LA Kings v SJ Sharks | W | 4-2 |
| NHL | 2021/04/10 02:30 | LA Kings v SJ Sharks | L | 2-5 |
| NHL | 2021/04/08 02:00 | ARZ Coyotes v LA Kings | W | 3-4 |
| NHL | 2021/04/06 02:00 | ARZ Coyotes v LA Kings | L | 5-2 |
| NHL | 2021/04/04 02:00 | SJ Sharks v LA Kings | L | 3-2 |
| NHL | 2021/04/03 02:00 | SJ Sharks v LA Kings | L | 3-0 |