Stadium: The Buc Dome
Home Manager: Becky Burke Away Manager: Clarisse Garcia
| WNCAAB | 2021/03/06 19:00 | USC Upstate (W) v Charleston Southern (W) | W | 72-64 |
| WNCAAB | 2020/02/12 00:00 | Charleston Southern (W) v USC Upstate (W) | W | 64-71 |
| WNCAAB | 2019/12/28 19:00 | USC Upstate (W) v Charleston Southern (W) | W | 70-53 |
| WNCAAB | 2019/03/12 23:00 | Charleston Southern (W) v USC Upstate (W) | L | 67-52 |
| WNCAAB | 2019/02/09 20:00 | Charleston Southern (W) v USC Upstate (W) | L | 74-62 |
| WNCAAB | 2019/01/19 19:00 | USC Upstate (W) v Charleston Southern (W) | L | 75-78 |
| WNCAAB | 2021/12/04 19:00 | UNC Greensboro Women v USC Upstate (W) | W | 46-57 |
| WNCAAB | 2021/12/02 00:30 | USC Upstate (W) v Western Carolina Women | W | 58-51 |
| WNCAAB | 2021/11/28 19:00 | USC Upstate (W) v Mars Hill Women | W | 102-40 |
| WNCAAB | 2021/11/22 23:00 | USC Upstate (W) v Florida Women | L | 54-76 |
| WNCAAB | 2021/11/19 23:00 | USC Upstate (W) v Columbia International Women | W | 81-40 |
| WNCAAB | 2021/11/17 00:00 | South Carolina State Women v USC Upstate (W) | W | 51-70 |
| WNCAAB | 2021/11/11 00:00 | USC Upstate (W) v Clemson (W) | L | 47-64 |
| WNCAAB | 2021/03/08 23:00 | USC Upstate (W) v High Point (W) | L | 63-85 |
| WNCAAB | 2021/12/05 19:00 | Charleston Southern (W) v Florida State (W) | L | 32-83 |
| WNCAAB | 2021/12/02 22:30 | Coll of Charleston (W) v Charleston Southern (W) | L | 96-60 |
| WNCAAB | 2021/11/29 23:00 | Charleston Southern (W) v Belmont Abbey Women | L | 48-56 |
| WNCAAB | 2021/11/26 18:00 | Charleston Southern (W) v Auburn (W) | L | 42-91 |
| WNCAAB | 2021/11/20 21:00 | Charleston Southern (W) v Western Carolina Women | L | 48-74 |
| WNCAAB | 2021/11/16 23:00 | George Mason (W) v Charleston Southern (W) | L | 64-55 |
| WNCAAB | 2021/11/09 23:00 | Charleston Southern (W) v Alabama (W) | L | 32-109 |
| WNCAAB | 2021/03/06 19:00 | USC Upstate (W) v Charleston Southern (W) | L | 72-64 |