Stadium: Clune Arena
Home Manager: Joe Scott Away Manager: Dave Dickerson
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | L | 79-83 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/03/09 21:30 | Air Force v Utah State | L | 56-83 |
| NCAAB | 2022/03/02 02:00 | San Jose State v Air Force | W | 54-58 |
| NCAAB | 2022/02/26 21:00 | Air Force v New Mexico | L | 65-69 |
| NCAAB | 2022/02/23 02:00 | Fresno St v Air Force | L | 65-40 |
| NCAAB | 2022/02/19 21:00 | Air Force v Wyoming | L | 67-75 |
| NCAAB | 2022/02/17 03:00 | Boise State v Air Force | L | 85-59 |
| NCAAB | 2022/02/13 01:00 | Air Force v San Diego St | L | 64-76 |
| NCAAB | 2022/02/08 08:27 | Air Force v UNLV | L | 44-78 |