Stadium: Enterprise Center
Home Manager: Jon Cooper Away Manager: Craig Berube
| NHL | 2021/12/03 00:00 | STL Blues v TB Lightning | W | 2-4 |
| NHL | 2021/12/01 01:00 | TB Lightning v STL Blues | L | 3-4 |
| NHL | 2019/11/28 00:00 | STL Blues v TB Lightning | L | 4-3 |
| NHL | 2019/11/20 01:00 | TB Lightning v STL Blues | L | 1-3 |
| NHL | 2019/03/24 00:00 | TB Lightning v STL Blues | L | 3-4 |
| NHL | 2019/02/08 00:30 | STL Blues v TB Lightning | L | 1-0 |
| NHL | 2017/12/13 01:00 | TB Lightning v STL Blues | W | 3-0 |
| NHL | 2017/10/14 23:00 | STL Blues v TB Lightning | W | 1-2 |
| NHL | 2022/06/27 00:00 | COL Avalanche v TB Lightning | L | 2-1 |
| NHL | 2022/06/25 00:00 | TB Lightning v COL Avalanche | W | 3-2 |
| NHL | 2022/06/23 00:00 | COL Avalanche v TB Lightning | L | 3-2 |
| NHL | 2022/06/21 00:00 | COL Avalanche v TB Lightning | W | 2-6 |
| NHL | 2022/06/19 00:00 | TB Lightning v COL Avalanche | L | 0-7 |
| NHL | 2022/06/16 00:00 | TB Lightning v COL Avalanche | L | 3-4 |
| NHL | 2022/06/12 00:00 | NY Rangers v TB Lightning | W | 1-2 |
| NHL | 2022/06/10 00:00 | TB Lightning v NY Rangers | W | 3-1 |
| NHL | 2022/05/28 00:00 | COL Avalanche v STL Blues | L | 3-2 |
| NHL | 2022/05/26 00:00 | STL Blues v COL Avalanche | W | 5-4 |
| NHL | 2022/05/24 01:30 | COL Avalanche v STL Blues | L | 6-3 |
| NHL | 2022/05/22 00:00 | COL Avalanche v STL Blues | L | 5-2 |
| NHL | 2022/05/20 01:30 | STL Blues v COL Avalanche | W | 4-1 |
| NHL | 2022/05/18 01:30 | STL Blues v COL Avalanche | L | 2-3 |
| NHL | 2022/05/13 01:30 | MIN Wild v STL Blues | W | 1-5 |
| NHL | 2022/05/11 01:30 | STL Blues v MIN Wild | W | 5-2 |