Stadium: Lincoln Financial Field Round: 205
Home Manager: Kyle Shanahan Away Manager: Nick Sirianni
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 3 | 10 | 0 | 13 | 23 |
| 6 | 7 | 13 | 3 | 3 | 19 |
| SF 49ers | PHI Eagles |
| Lineup | |
|---|---|
| 99 - DT - CJ West | Jalen Carter - DT - 98 |
| 36 - SAF - Marques Sigle | Jahan Dotson - WR - 2 |
| 77 - OL - Dominick Puni | Moro Ojomo - DT - 97 |
| 95 - DT - Alfred Collins | Cameron Latu - TE - 36 |
| 68 - OL - Colton McKivitz | Tyler Steen - OL - 56 |
| 29 - Right back - Jordan James | Britain Covey - WR - 18 |
| 2 - DB - Deommodore Lenoir | Jeremiah Trotter - Left back - 54 |
| 92 - DT - Jordan Elliott | Andre Sam - SAF - 31 |
| 75 - OL - Connor Colby | Reed Blankenship - SAF - 32 |
| 94 - DE - Yetur Gross-Matos | Braden Mann - Pivot - 10 |
| 61 - OL - Matt Hennessy | Kelee Ringo - DB - 7 |
| 25 - Center back - Jason Pinnock | Grant Calcaterra - TE - 81 |
| 20 - DB - Upton Stout | Sydney Brown - SAF - 21 |
| 62 - OL - Austen Pleasants | Cameron Jurgens - OL - 51 |
| 28 - Center back - Darrell Luter Jr. | Quinyon Mitchell - Center back - 27 |
| 6 - DB - Malik Mustapha | Tank Bigsby - Right back - 37 |
| 89 - TE - Luke Farrell | Zack Baun - OLB - 53 |
| 96 - DE - Clelin Ferrell | Byron Young - DL - 94 |
| 47 - Left back - Bryce Huff | Jalyx Hunt - DL - 58 |
| 59 - OLB - Curtis Robinson | Jalen Hurts - QB - 1 |
| 33 - Center back - Siran Neal | Nakobe Dean - Left back - 17 |
| 84 - WR - Kendrick Bourne | Nolan Smith - Left back - 3 |
| 85 - TE - George Kittle | DeVonta Smith - WR - 6 |
| 44 - FB - Kyle Juszczyk | Jordan Mailata - OT - 68 |
| 23 - Right back - Christian McCaffrey | Saquon Barkley - Right back - 26 |
| 5 - WR - Demarcus Robinson | Mac McWilliams - DB - 22 |
| 64 - OL - Jake Brendel | A.J. Brown - WR - 11 |
| 43 - Left back - Eric Kendricks | Drew Kendall - OL - 66 |
| 46 - LS - Jon Weeks | Landon Dickerson - Center - 69 |
| 71 - OL - Trent Williams | Michael Carter II - Center back - 35 |
| 18 - K - Eddy Pineiro | Adoree Jackson - ATH - 8 |
| 15 - WR - Jauan Jennings | Jaelan Phillips - Left back - 50 |
| 27 - SAF - Ji'Ayir Brown | Kylen Granson - TE - 83 |
| 9 - WR - Skyy Moore | Charley Hughlett - LS - 47 |
| 91 - DT - Sam Okuayinonu | Jihaad Campbell - Left back - 30 |
| 41 - SAF - Jalen Graham | Brandon Graham - DE - 55 |
| - DB - Renardo Green | Jake Elliott - K - 4 |
| 74 - OL - Spencer Burford | Will Shipley - Right back - 28 |
| 51 - Left back - Robert Beal Jr. | Dallas Goedert - TE - 88 |
| 13 - QB - Brock Purdy | Darius Cooper - WR - 80 |
| 88 - TE - Jake Tonges | Jordan Davis - DT - 90 |
| 3 - Right back - Brian Robinson | Matt Pryor - OG - 79 |
| 49 - Left back - Garret Wallow | Fred Johnson - OL - 74 |
| 56 - DL - Keion White | Cooper DeJean - DB - 33 |
| 93 - DL - Kalia Davis | Smael Mondon - Left back - 42 |
| 81 - WR - Malik Turner | Marcus Epps - SS - 39 |
| 7 - K - Thomas Morstead | - |
| Substitutes | |