Stadium: Highmark Stadium Round: 8
Home Manager: Doug Pederson Away Manager: Sean McDermott
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 8 | 11 | 13 | 7 | 31 |
| 0 | 7 | 7 | 6 | 0 | 13 |
| PHI Eagles | BUF Bills |
| Lineup | |
|---|---|
| 19 - WR - J.J. Arcega-Whiteside | Dawson Knox - TE - 88 |
| 90 - DT - Bruce Hector | Kyle Peko - DT - 94 |
| 88 - TE - Dallas Goedert | Duke Williams - WR - 82 |
| 57 - Left back - T.J. Edwards | Reid Ferguson - LS - 69 |
| 35 - Right back - Boston Scott | Jaquan Johnson - SAF - 46 |
| 17 - WR - Alshon Jeffery | Shaq Lawson - DE - 90 |
| 66 - DT - Anthony Rush | Maurice Alexander - OLB - 41 |
| 86 - TE - Zach Ertz | Quinton Spain - OG - 67 |
| 77 - OT - Andre Dillard | Dean Marlowe - SAF - 31 |
| 23 - SAF - Rodney McLeod | Jon Feliciano - OG - 76 |
| 76 - DT - Albert Huggins | Mitch Morse - Center - 60 |
| 19 - DE - Josh Sweat | Jordan Phillips - DE - 97 |
| 24 - Right back - Jordan Howard | Tyler Kroft - TE - 81 |
| 51 - OLB - Shareef Miller | Tre'Davious White - Center back - 27 |
| 26 - Right back - Miles Sanders | Dion Dawkins - OT - 73 |
| 69 - OL - Matt Pryor | Ed Oliver - DT - 91 |
| 79 - OG - Brandon Brooks | Cody Ford - OL - 70 |
| 39 - Center back - Craig James | Levi Wallace - Center back - 39 |
| 1 - Pivot - Cameron Johnston | Robert Foster - WR - 16 |
| 36 - SAF - Rudy Ford | Tremaine Edmunds - Left back - 49 |
| 73 - OL - Isaac Seumalo | Josh Allen - QB - 17 |
| 11 - QB - Carson Wentz | Corey Bojorquez - Pivot - 9 |
| 49 - LS - Rick Lovato | Devin Singletary - Right back - 26 |
| 18 - QB - Josh McCown | Darryl Johnson - DE - 92 |
| 49 - Left back - Alex Singleton | Siran Neal - Center back - 33 |
| 65 - OT - Lane Johnson | Taron Johnson - Center back - 7 |
| 55 - DE - Brandon Graham | Matt Milano - Left back - 58 |
| 75 - DE - Vinny Curry | Kevin Johnson - Center back - 29 |
| 91 - DT - Fletcher Cox | Andre Roberts - WR - 18 |
| 21 - Center back - Ronald Darby | Julian Stanford - Left back - 51 |
| 13 - WR - Nelson Agholor | Patrick DiMarco - FB - 42 |
| 7 - QB - Nate Sudfeld | Micah Hyde - SAF - 23 |
| 31 - Center back - Jalen Mills | Star Lotulelei - DT - 98 |
| 72 - OT - Halapoulivaati Vaitai | Steven Hauschka - K - 4 |
| 47 - Left back - Nathan Gerry | John Brown - WR - 15 |
| 42 - SS - Andrew Sendejo | Senorise Perry - Right back - 32 |
| 4 - K - Jake Elliott | Cole Beasley - WR - 10 |
| 16 - WR - Mack Hollins | Matt Barkley - QB - 5 |
| 50 - Left back - Duke Riley | Jerry Hughes - DE - 55 |
| 22 - Center back - Sidney Jones | Jordan Poyer - SAF - 21 |
| 32 - Center back - Rasul Douglas | Lee Smith - TE - 85 |
| 74 - DE - Daeshon Hall | Spencer Long - OL - 61 |
| 62 - Center - Jason Kelce | Frank Gore - Right back - 20 |
| 96 - DE - Derek Barnett | Lorenzo Alexander - OLB - 57 |
| 54 - Left back - Kamu Grugier-Hill | Ty Nsekhe - OT - 77 |
| 27 - SS - Malcolm Jenkins | Trent Murphy - DE - 93 |
| Substitutes | |