Stadium: Northwest Stadium Round: 17
Home Manager: Kyle Shanahan Away Manager: Ron Rivera
| 1 | 2 | H | 3 | 4 | F | 
|---|---|---|---|---|---|
| 10 | 3 | 13 | 7 | 7 | 27 | 
| 0 | 10 | 10 | 0 | 0 | 10 | 
| SF 49ers | WAS Commanders | 
| Lineup | |
|---|---|
| 64 - OL - Jake Brendel | Nick Whiteside - Center back - 37 | 
| 99 - DT - Javon Kinlaw | Dyami Brown - WR - 2 | 
| 5 - DE - Randy Gregory | K.J. Henry - DL - 55 | 
| 35 - SAF - Erik Harris | Tariq Castro-Fields - Center back - 26 | 
| 55 - OL - Jon Feliciano | Samuel Cosmi - OL - 76 | 
| 92 - DE - Chase Young | Phidarian Mathis - DL - 98 | 
| 28 - Center back - Darrell Luter Jr. | John Ridgeway - DL - 91 | 
| 84 - WR - Chris Conley | Brian Robinson - Right back - 8 | 
| 68 - OL - Colton McKivitz | Chris Paul - OL - 75 | 
| 2 - DB - Deommodore Lenoir | Nick Gates - OL - 63 | 
| 44 - FB - Kyle Juszczyk | Cody Barton - Left back - 57 | 
| 20 - Center back - Ambry Thomas | Terrell Burgess - DB - 32 | 
| 65 - OG - Aaron Banks | Byron Pringle - WR - 16 | 
| 33 - DB - Logan Ryan | Terry McLaurin - WR - 17 | 
| 71 - OL - Trent Williams | Jartavius Martin - Center back - 20 | 
| 78 - OL - Ben Bartch | Jahan Dotson - WR - 1 | 
| 31 - SAF - Tashaun Gipson | Trenton Scott - OT - 73 | 
| 11 - WR - Brandon Aiyuk | Jabril Cox - Left back - 41 | 
| 57 - Left back - Dre Greenlaw | James Smith-Williams - DE - 96 | 
| 89 - TE - Charlie Woerner | Casey Toohill - DE - 95 | 
| 53 - Left back - Dee Winters | Antonio Gibson - WR - 24 | 
| 98 - DT - Javon Hargrave | Khaleke Hudson - Left back - 47 | 
| 4 - K - Jake Moody | Kamren Curl - DB - 31 | 
| 25 - Right back - Elijah Mitchell | De'Jon Harris - Left back - 45 | 
| 86 - WR - Tay Martin | Saahdiq Charles - OT - 77 | 
| 48 - Left back - Oren Burks | Emmanuel Forbes - Center back - 13 | 
| 7 - Center back - Charvarius Ward | Derrick Gore - Right back - 38 | 
| 18 - Pivot - Mitch Wishnowsky | Joshua Pryor - DL - 59 | 
| 75 - OG - Matt Pryor | Christian Holmes - DB - 34 | 
| 90 - DT - Kevin Givens | Kyu Blu Kelly - Center back - 36 | 
| 45 - SAF - Demetrius Flannigan-Fowles | Sam Howell - QB - 14 | 
| 19 - WR - Deebo Samuel | Daron Payne - DL - 94 | 
| 14 - QB - Sam Darnold | Tress Way - Pivot - 10 | 
| 94 - DE - Clelin Ferrell | Alex Armah - FB - 40 | 
| 51 - Left back - Robert Beal Jr. | Jonathan Allen - DL - 93 | 
| 85 - TE - George Kittle | Andre Jones Jr. - Left back - 50 | 
| 69 - DL - Sebastian Joseph-Day | John Bates - TE - 87 | 
| 74 - OL - Spencer Burford | Joey Slye - K - 6 | 
| 24 - Right back - Jordan Mason | Alex Akingbulu - T - 62 | 
| 46 - LS - Taybor Pepper | Tucker Addington - - 58 | 
| 26 - Center back - Isaiah Oliver | Jamison Crowder - WR - 83 | 
| 10 - WR - Ronnie Bell | Curtis Samuel - Right back - 4 | 
| 23 - Right back - Christian McCaffrey | Sean Chandler - DB - 48 | 
| 97 - DL - Nick Bosa | David Mayo - Left back - 51 | 
| 9 - FB - Brayden Willis | Logan Thomas - QB - 82 | 
| 13 - QB - Brock Purdy | Cornelius Lucas - OL - 78 | 
| - DB - Samuel Womack III | - | 
| 54 - Left back - Fred Warner | - | 
| Substitutes | |