Stadium: G.B. Hodge Center Round: 1
Home Manager: Tammy George Away Manager: Fred Applin
| WNCAAB | 2018/03/03 01:00 | Lipscomb Women v USC Upstate (W) | L | 95-53 |
| WNCAAB | 2018/02/24 18:00 | USC Upstate (W) v NJIT (W) | W | 74-67 |
| WNCAAB | 2018/02/20 00:00 | North Florida (W) v USC Upstate (W) | L | 79-61 |
| WNCAAB | 2018/02/17 18:00 | Jacksonville Women v USC Upstate (W) | L | 65-49 |
| WNCAAB | 2018/02/13 00:00 | USC Upstate (W) v Stetson Women | W | 69-64 |
| WNCAAB | 2018/02/10 18:30 | USC Upstate (W) v Florida Gulf Coast (W) | L | 44-88 |
| WNCAAB | 2018/02/08 00:00 | USC Upstate (W) v Lipscomb Women | W | 80-64 |
| WNCAAB | 2018/02/03 19:00 | Kennesaw State (W) v USC Upstate (W) | W | 64-70 |
| WNCAAB | 2018/03/09 17:00 | Liberty (W) v Charleston Southern (W) | L | 80-53 |
| WNCAAB | 2018/03/08 23:00 | Charleston Southern (W) v Longwood (W) | W | 72-62 |
| WNCAAB | 2018/03/03 20:00 | Charleston Southern (W) v Presbyterian (W) | L | 58-81 |
| WNCAAB | 2018/02/28 00:00 | Winthrop (W) v Charleston Southern (W) | L | 62-56 |
| WNCAAB | 2018/02/24 20:00 | Charleston Southern (W) v Liberty (W) | L | 57-95 |
| WNCAAB | 2018/02/21 00:00 | High Point (W) v Charleston Southern (W) | L | 52-49 |
| WNCAAB | 2018/02/17 20:00 | Charleston Southern (W) v Gardner Webb Women | L | 59-75 |
| WNCAAB | 2018/02/14 00:00 | UNC Asheville Women v Charleston Southern (W) | L | 71-69 |