[12] PHI Flyers 3-6 BUF Sabres [6] 2021-09-04 18:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Yeo
Head to Head
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | L | 5-3 |
| NHL | 2021/03/31 23:30 | PHI Flyers v BUF Sabres | L | 1-6 |
| NHL | 2021/03/29 23:00 | PHI Flyers v BUF Sabres | W | 4-3 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | W | 4-5 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/01/20 00:00 | BUF Sabres v PHI Flyers | W | 0-3 |
| NHL | 2021/01/19 00:30 | BUF Sabres v PHI Flyers | L | 6-1 |
Home History
| NHL | 2021/05/10 23:00 | NJ Devils v PHI Flyers | W | 2-4 |
| NHL | 2021/05/08 23:00 | PHI Flyers v WAS Capitals | L | 1-2 |
| NHL | 2021/05/07 23:00 | PHI Flyers v WAS Capitals | W | 4-2 |
| NHL | 2021/05/04 23:00 | PIT Penguins v PHI Flyers | L | 7-3 |
| NHL | 2021/05/03 23:00 | PIT Penguins v PHI Flyers | W | 2-7 |
| NHL | 2021/05/01 23:00 | NJ Devils v PHI Flyers | L | 4-1 |
| NHL | 2021/04/29 23:00 | PHI Flyers v NJ Devils | L | 3-5 |
| NHL | 2021/04/27 23:00 | PHI Flyers v NJ Devils | L | 4-6 |
Away History
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | W | 2-4 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | L | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | L | 2-5 |
| NHL | 2021/04/27 23:00 | BUF Sabres v NY Rangers | L | 1-3 |
| NHL | 2021/04/25 22:00 | BUF Sabres v NY Rangers | L | 3-6 |
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