[18] Reilly Opelka 6-3,7-6 John Isner [27] 2021-11-11 19:00
Stadium: Stadium Court Round: 29 Ground: Clay
Head to Head
| ATP Atlanta | 2019/07/24 23:00 | John Isner v Reilly Opelka | 6-7,7-6,6-7 |
| ATP New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
Home History
| ATP Paris | 2021/11/03 13:35 | Cameron Norrie v Reilly Opelka | 6-3,6-4 |
| ATP Paris | 2021/11/02 11:30 | Filip Krajinovic v Reilly Opelka | 3-6,6-7 |
| ATP Vienna | 2021/10/27 12:00 | Reilly Opelka v Jannik Sinner | 4-6,2-6 |
| ATP Antwerp | 2021/10/19 14:15 | Reilly Opelka v Jenson Brooksby | 4-6,4-6 |
| ATP Indian Wells | 2021/10/11 20:35 | Grigor Dimitrov v Reilly Opelka | 6-3,6-4 |
| ATP Indian Wells | 2021/10/09 18:00 | Taro Daniel v Reilly Opelka | 5-7,3-6 |
| Laver Cup | 2021/09/24 17:00 | Casper Ruud v Reilly Opelka | 6-3,7-6 |
| US Open | 2021/09/06 17:25 | Reilly Opelka v Lloyd Harris | 7-6,4-6,1-6,3-6 |
Away History
| ATP Indian Wells | 2021/10/11 03:30 | John Isner v Yoshihito Nishioka | 6-3,6-4 |
| Laver Cup | 2021/09/25 18:50 | Alexander Zverev v John Isner | 7-6,6-7,10-5 |
| US Open | 2021/08/30 17:35 | John Isner v Brandon Nakashima | 6-7,6-7,3-6 |
| ATP Cincinnati | 2021/08/19 16:05 | John Isner v Benoit Paire | 6-7,7-6,1-6 |
| ATP Cincinnati | 2021/08/18 19:35 | Jannik Sinner v John Isner | 7-5,6-7,4-6 |
| ATP Cincinnati | 2021/08/17 17:55 | John Isner v Cameron Norrie | 4-6,7-6,6-4 |
| ATP Toronto | 2021/08/15 00:00 | Daniil Medvedev v John Isner | 6-2,6-2 |
| ATP Toronto | 2021/08/14 01:35 | John Isner v Gael Monfils | 7-6,6-4 |
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