Head to Head
| Mexico Liga MX Femenil | 2022/02/08 01:00 | Santos Laguna (W) v Leon (W) | L | 1-3 |
| Mexico Liga MX Femenil | 2021/08/24 00:00 | Leon (W) v Santos Laguna (W) | W | 1-6 |
| Mexico Liga MX Femenil | 2021/02/04 23:00 | Leon (W) v Santos Laguna (W) | L | 2-1 |
| Mexico Liga MX Femenil | 2020/09/22 00:00 | Santos Laguna (W) v Leon (W) | D | 1-1 |
| Mexico Liga MX Femenil | 2020/02/25 03:00 | Santos Laguna (W) v Leon (W) | L | 1-2 |
| Mexico Liga MX Femenil | 2019/09/24 00:00 | Leon (W) v Santos Laguna (W) | L | 2-0 |
| Mexico Liga MX Femenil | 2019/04/02 03:00 | Leon (W) v Santos Laguna (W) | L | 1-0 |
| Mexico Liga MX Femenil | 2019/02/05 01:00 | Santos Laguna (W) v Leon (W) | L | 0-1 |
Home History
| Mexico Liga MX Femenil | 2022/04/26 00:00 | Santos Laguna (W) v Juarez FC (W) | W | 3-1 |
| Mexico Liga MX Femenil | 2022/04/19 00:00 | Tigres UANL (W) v Santos Laguna (W) | L | 4-1 |
| Mexico Liga MX Femenil | 2022/04/12 00:00 | Santos Laguna (W) v Club America (W) | L | 0-3 |
| Mexico Liga MX Femenil | 2022/04/01 03:00 | Santos Laguna (W) v Puebla (W) | D | 0-0 |
| Mexico Liga MX Femenil | 2022/03/27 16:00 | Monterrey (W) v Santos Laguna (W) | L | 3-1 |
| Mexico Liga MX Femenil | 2022/03/20 23:00 | Atletico San Luis (W) v Santos Laguna (W) | W | 2-4 |
| Mexico Liga MX Femenil | 2022/03/18 01:00 | Santos Laguna (W) v Pachuca (W) | L | 0-1 |
| Mexico Liga MX Femenil | 2022/03/12 18:00 | Cruz Azul (W) v Santos Laguna (W) | W | 2-3 |
Away History
| Mexico Liga MX Femenil | 2022/04/26 00:00 | Leon (W) v Toluca (W) | D | 2-2 |
| Mexico Liga MX Femenil | 2022/04/16 22:00 | Atletico San Luis (W) v Leon (W) | L | 4-0 |
| Mexico Liga MX Femenil | 2022/04/11 00:00 | Leon (W) v Monterrey (W) | L | 1-6 |
| Mexico Liga MX Femenil | 2022/04/01 03:00 | Leon (W) v Cruz Azul (W) | L | 2-3 |
| Mexico Liga MX Femenil | 2022/03/29 03:00 | Leon (W) v Chivas Guadalajara (W) | L | 0-2 |
| Mexico Liga MX Femenil | 2022/03/22 01:00 | Tigres UANL (W) v Leon (W) | L | 6-0 |
| Mexico Liga MX Femenil | 2022/03/17 16:00 | Leon (W) v Puebla (W) | W | 2-0 |
| Mexico Liga MX Femenil | 2022/03/13 01:00 | Mazatlan FC (W) v Leon (W) | D | 0-0 |
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